Description:
The combination of amoxicillin and colistin acts additive. amoxicillin is a semisynthetic broad-spectrum penicillin with a bactericidal action against both Gram-positive and Gram-negative bacteria. The range of effect includes Campylobacter, Clostridium, Corynebacterium, E. coli, Erysipelothrix, Haemophilus, Pasteurella, Salmonella, penicillinase-negative Staphylococcus and Streptococcus, spp. The bactericidal action is due to inhibition of cell wall synthesis. amoxicillin is mainly excreted in urine. A major part can also be excreted in bile. Colistin is an antibiotic from the group of polymyxins with a bactericidal action against Gram-negative bacteria like E. coli, Haemophilus and Salmonella. Since colistin is absorbed for a very small part after oral administration only gastrointestinal indications are relevant.
Information
Composition:
Contains per gram powder:
Colistin sulphate ……………………………………………………………………………… 1 200 000 IU.
amoxicillin trihydrate ……………………………………………………………………………….. 200 mg.
Carrier ad …………………………………………………………………………………………………… 1 g.
Indications:
Gastrointestinal, respiratory and urinary tract infections caused by amoxicillin and colistin sensitive micro-organisms, like Campylobacter, Clostridium, Corynebacterium, E. coli, Erysipelothrix, Haemophilus, Pasteurella, Salmonella, penicillinase negative Staphylococcus and Streptococcus spp. in calves, goats, poultry, sheep and swine.
Contra-indications:
Hypersensitivity to amoxicillin and/or colistin.
Administration to animals with a seriously impaired renal function.
Concurrent administration of tetracyclines, chloramphenicol, macrolides and lincosamides.
Administration to animals with an active microbial digestion.
Side effects:
Hypersensitivity reactions, renal dysfunction, neurotoxicity and neuromuscular blockade.
Packaging:
Sachet of 100 g and jar of 500 and 1000 g
Usage
Dosage:
For oral administration:
Calves, goats and sheep : Twice daily 5 g per 100 kg body weight for 3 – 5 days.
Poultry and swine : 1 kg per 1000 – 2000 litres of drinking water for 3 – 5 days.
Note: for pre-ruminant calves, lambs and kids only.
Please note: Before adding to the drinking water make a presolution of 1 kg Dimoxan WS per 20 litres of water with a temperature of 40 °C.
